Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gria3. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Gria3
  • is located in the following cellular components:
    • alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex ^[3]
    • membrane ^[2]
• The gene product of Gria3 has been shown to bind to the gene products of Gria2. ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gria3:
  • participates in the following biological processes:
    • ionotropic glutamate receptor signaling pathway
    • regulation of receptor recycling
  • performs the following molecular functions:
    • alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
    • ionotropic glutamate receptor activity
    • PDZ domain binding
  • is located in the following cellular components:
    • alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
    • asymmetric synapse
    • dendrite
    • dendritic shaft
    • dendritic spine
    • neuronal cell body
    • perikaryon
    • postsynaptic density
    • protein complex
    • synaptic cleft
    • terminal button

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Summary text based on GO annotations supported by structural data

• Gria3 encodes a protein or proteins that contain the following InterPro domains: Extracellular ligand-binding receptor, Glutamate receptor, L-glutamate/glycine-binding, Ionotropic glutamate receptor, NMDA receptor, indicating that the gene product:
  • participates in the following biological processes:
    • ion transport
  • performs the following molecular functions:
    • extracellular-glutamate-gated ion channel activity
    • ion channel activity
    • receptor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gria3 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • ion channel activity
  • is located in the following cellular components:
    • cell junction
    • integral to membrane
    • plasma membrane
    • postsynaptic membrane
    • synapse

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References

1. Kolleker A et al. (2003) Glutamatergic plasticity by synaptic delivery of GluR-B long-containing AMPA receptors. Neuron, 40:1199-212. (PubMed:14687553)
2. Lai C et al. (2006) Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. J Neurosci, 26:11798-806. (PubMed:17093100)
3. Schwenk J et al. (2012) High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Neuron, 74:621-33. (PubMed:22632720)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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