Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gsr. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Gsr
  • participates in the following biological processes:
    • oxidation-reduction process ^{[1, 2, 5, 6]}
  • performs the following molecular functions:
    • glutathione-disulfide reductase activity ^{[1, 2, 5, 6]}
  • is located in the following cellular components:
    • mitochondrion ^{[3, 4]}
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Gsr
  • participates in the following biological processes:
    • glutathione metabolic process ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gsr:
  • participates in the following biological processes:
    • glutathione metabolic process
    • oxidation-reduction process
    • spermatogenesis
  • performs the following molecular functions:
    • flavin adenine dinucleotide binding
    • glutathione binding
    • glutathione-disulfide reductase activity
    • NADP binding
    • protein homodimerization activity
  • is located in the following cellular components:
    • cytosol
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Gsr encodes a protein or proteins that contain the following InterPro domains: FAD-dependent pyridine nucleotide-disulphide oxidoreductase, FAD/NAD-linked reductase, dimerisation, Glutathione reductase, eukaryote/bacterial, Pyridine nucleotide-disulphide oxidoreductase, class I, active site, Pyridine nucleotide-disulphide oxidoreductase, dimerisation, Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain, indicating that the gene product:
  • participates in the following biological processes:
    • cell redox homeostasis
  • performs the following molecular functions:
    • oxidoreductase activity
    • oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gsr indicates that it:
  • performs the following molecular functions:
    • oxidoreductase activity
  • is located in the following cellular components:
    • cytoplasm

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References

1. Kozak C et al. (1975) Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome. Somatic Cell Genet, 1:371-82. (PubMed:1235912)
2. Kozak CA et al. (1977) Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids. Somatic Cell Genet, 3:121-33. (PubMed:204065)
3. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
4. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
5. Stallings RL et al. (1981) Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7. Somatic Cell Genet, 7:683-98. (PubMed:7323947)
6. White RA et al. (1990) Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of the nb allele is associated with a truncated erythrocyte ankyrin. Proc Natl Acad Sci U S A, 87:3117-21. (PubMed:2139228)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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