Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gnat2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 19, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Gnat2
  • participates in the following biological processes:
    • detection of light stimulus involved in visual perception ^[2]
    • phototransduction ^{[3, 4]}
    • retinal cone cell development ^{[2, 5]}
    • visual perception ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gnat2:
  • participates in the following biological processes:
    • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
    • detection of chemical stimulus involved in sensory perception of bitter taste
    • detection of light stimulus involved in visual perception
    • rhodopsin mediated signaling pathway
  • performs the following molecular functions:
    • G-protein beta/gamma-subunit complex binding
    • G-protein coupled receptor binding
    • GTPase activity
    • signal transducer activity
  • is located in the following cellular components:
    • extrinsic to internal side of plasma membrane
    • heterotrimeric G-protein complex
    • photoreceptor inner segment
    • photoreceptor outer segment

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Summary text based on GO annotations supported by structural data

• Gnat2 encodes a protein or proteins that contain the following InterPro domains: G protein alpha subunit, helical insertion, G-protein alpha subunit, group I, Guanine nucleotide binding protein (G-protein), alpha subunit, indicating that the gene product:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • GTP binding
    • guanyl nucleotide binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gnat2 indicates that it:
  • participates in the following biological processes:
    • response to stimulus
    • signal transduction
  • performs the following molecular functions:
    • GTP binding
    • metal ion binding
    • nucleotide binding

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References

1. Alexander JJ et al. (2007) Restoration of cone vision in a mouse model of achromatopsia. Nat Med, 13:685-7. (PubMed:17515894)
2. Chang B et al. (2006) Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2. Invest Ophthalmol Vis Sci, 47:5017-21. (PubMed:17065522)
3. Nusinowitz S et al. (2007) Temporal response properties of the primary and secondary rod-signaling pathways in normal and Gnat2 mutant mice. Exp Eye Res, 84:1104-14. (PubMed:17408617)
4. Umino Y et al. (2008) Speed, spatial, and temporal tuning of rod and cone vision in mouse. J Neurosci, 28:189-98. (PubMed:18171936)
5. Won J et al. (2011) Mouse model resources for vision research. J Ophthalmol, 2011:391384. (PubMed:21052544)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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