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Gene Ontology Classifications
solute carrier family 2 (facilitated glucose transporter), member 4

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GO curators for mouse genes have assigned the following annotations to the gene product of Slc2a4. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Barnes BR et al. (2005) 5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics. FASEB J, 19:773-9. (PubMed:15857891)
  2. Blanc L et al. (2009) The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume. Blood, 114:3928-34. (PubMed:19724054)
  3. Bogan JS et al. (1999) Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. J Cell Biol, 146:609-20. (PubMed:10444069)
  4. Bogan JS et al. (2003) Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature, 425:727-33. (PubMed:14562105)
  5. Bose A et al. (2002) Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Nature, 420:821-4. (PubMed:12490950)
  6. Fecchi K et al. (2006) Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells. FASEB J, 20:705-7. (PubMed:16455755)
  7. Gray S et al. (2002) The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. J Biol Chem, 277:34322-8. (PubMed:12097321)
  8. Guilherme A et al. (2004) Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. J Biol Chem, 279:40062-75. (PubMed:15247266)
  9. Hatanaka T et al. (2006) Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2. J Biol Chem, 281:35922-30. (PubMed:17003038)
  10. Hosaka T et al. (2005) p115 Interacts with the GLUT4 vesicle protein, IRAP, and plays a critical role in insulin-stimulated GLUT4 translocation. Mol Biol Cell, 16:2882-90. (PubMed:15800058)
  11. Jiang X et al. (2008) The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake. Am J Pathol, 172:1748-56. (PubMed:18511518)
  12. Macaulay SL et al. (2002) Cellular munc18c levels can modulate glucose transport rate and GLUT4 translocation in 3T3L1 cells. FEBS Lett, 528:154-60. (PubMed:12297296)
  13. MaCaulay SL et al. (2003) Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. Biochem J, 376:123-34. (PubMed:12917015)
  14. Schwenk RW et al. (2010) Requirement for distinct vesicle-associated membrane proteins in insulin- and AMP-activated protein kinase (AMPK)-induced translocation of GLUT4 and CD36 in cultured cardiomyocytes. Diabetologia, 53:2209-19. (PubMed:20582536)
  15. Taguchi A et al. (2008) Identification of Glypican3 as a novel GLUT4-binding protein. Biochem Biophys Res Commun, 369:1204-8. (PubMed:18343214)
  16. Waller AP et al. (2013) GLUT12 functions as a basal and insulin-independent glucose transporter in the heart. Biochim Biophys Acta, 1832:121-7. (PubMed:23041416)
  17. Widberg CH et al. (2003) Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. J Biol Chem, 278:35093-101. (PubMed:12832401)
  18. Williams D et al. (2008) Mapping of R-SNARE function at distinct intracellular GLUT4 trafficking steps in adipocytes. J Cell Biol, 180:375-87. (PubMed:18227281)
  19. Wu Y et al. (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab, 295:E205-15. (PubMed:18492766)
  20. Xie X et al. (2011) C2 Domain-Containing Phosphoprotein CDP138 Regulates GLUT4 Insertion into the Plasma Membrane. Cell Metab, 14:378-89. (PubMed:21907143)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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