Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables extracellularly glycine-gated chloride channel activity; glycine binding activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within several processes, including adult walking behavior; chemical synaptic transmission; and gamma-aminobutyric acid receptor clustering. Located in GABA-ergic synapse; dendrite; and membrane. Is active in glycinergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Used to study hyperekplexia 2. Human ortholog(s) of this gene implicated in hyperekplexia 2. Orthologous to human GLRB (glycine receptor beta).