Automated description from the Alliance of Genome Resources
Exhibits lactoylglutathione lyase activity and zinc ion binding activity. Involved in osteoclast differentiation and regulation of transcription by RNA polymerase II. Predicted to localize to the cytosol; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal failure; type 2 diabetes mellitus; and vascular disease. Is expressed in central nervous system and retina. Orthologous to human GLO1 (glyoxalase I).