Automated description from the Alliance of Genome Resources
Exhibits DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of cell differentiation. Localizes to the axoneme; nuclear speck; and transcriptional repressor complex. Used to study Greig cephalopolysyndactyly syndrome and Pallister-Hall syndrome. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (GLI family zinc finger 3).