Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including animal organ development; chordate embryonic development; and positive regulation of nervous system development. Localizes to several cellular components, including axoneme; ciliary tip; and nuclear speck. Human ortholog(s) of this gene implicated in Culler-Jones syndrome; holoprosencephaly 9; and spina bifida. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Orthologous to human GLI2 (GLI family zinc finger 2).