About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Gja5
gap junction protein, alpha 5
MGI:95716

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gja5. (This text reflects annotations as of Thursday, January 16, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Bevilacqua LM et al. (2000) A targeted disruption in connexin40 leads to distinct atrioventricular conduction defects. J Interv Card Electrophysiol, 4:459-67. (PubMed:11046183)
  2. Buschmann I et al. (2010) Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis. Development, 137:2187-96. (PubMed:20530546)
  3. de Wit C et al. (2000) Impaired conduction of vasodilation along arterioles in connexin40-deficient mice. Circ Res, 86:649-55. (PubMed:10747000)
  4. Frank DU et al. (2011) Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis. Proc Natl Acad Sci U S A, null:null. (PubMed:22203979)
  5. Kirchhoff S et al. (2000) Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient mice. Circ Res, 87:399-405. (PubMed:10969038)
  6. Kirchhoff S et al. (1998) Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice. Curr Biol, 8:299-302. (PubMed:9501070)
  7. Leaf DE et al. (2008) Connexin40 imparts conduction heterogeneity to atrial tissue. Circ Res, 103:1001-8. (PubMed:18599871)
  8. Pizard A et al. (2005) Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum. Mol Cell Biol, 25:5073-83. (PubMed:15923624)
  9. Simon AM et al. (1998) Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr Biol, 8:295-8. (PubMed:9501069)
  10. Simon AM et al. (2004) Heart and head defects in mice lacking pairs of connexins. Dev Biol, 265:369-83. (PubMed:14732399)
  11. Simon AM et al. (2002) Vascular Abnormalities in Mice Lacking the Endothelial Gap Junction Proteins connexin37 and connexin40. Dev Biol, 251:206-20. (PubMed:12435353)
  12. Verheule S et al. (1999) Cardiac conduction abnormalities in mice lacking the gap junction protein connexin40. J Cardiovasc Electrophysiol, 10:1380-9. (PubMed:10515563)
  13. Wagner C et al. (2007) Connexin40 is essential for the pressure control of renin synthesis and secretion. Circ Res, 100:556-63. (PubMed:17255527)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/01/2014
MGI 5.18
The Jackson Laboratory