Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ghr. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ghr
  • participates in the following biological processes:
    • cytokine-mediated signaling pathway ^[3]
    • growth hormone receptor signaling pathway ^[6]
    • positive regulation of peptidyl-tyrosine phosphorylation ^[6]
    • regulation of multicellular organism growth ^[5]
  • performs the following molecular functions:
    • growth hormone receptor activity ^[3]
  • is located in the following cellular components:
    • extrinsic to membrane ^[1]
    • nucleus ^[4]
    • plasma membrane ^[4]
• The gene product of Ghr has been shown to bind to the gene products of Stat5a. ^[6] Researchers have inferred, based on physical interactions, that the gene product of Ghr
  • performs the following molecular functions:
    • peptide hormone binding ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ghr
  • participates in the following biological processes:
    • 2-oxoglutarate metabolic process ^[5]
    • allantoin metabolic process ^[5]
    • citrate metabolic process ^[5]
    • creatine metabolic process ^[5]
    • creatinine metabolic process ^[5]
    • fatty acid metabolic process ^[5]
    • isoleucine metabolic process ^[5]
    • oxaloacetate metabolic process ^[5]
    • succinate metabolic process ^[5]
    • taurine metabolic process ^[5]
    • valine metabolic process ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ghr:
  • participates in the following biological processes:
    • activation of JAK2 kinase activity
    • activation of Janus kinase activity
    • activation of MAPK activity
    • cellular response to hormone stimulus
    • growth hormone receptor signaling pathway
    • hormone-mediated signaling pathway
    • insulin-like growth factor receptor signaling pathway
    • JAK-STAT cascade
    • multicellular organismal metabolic process
    • negative regulation of neuron death
    • positive regulation of JAK-STAT cascade
    • positive regulation of multicellular organism growth
    • receptor internalization
    • response to cycloheximide
    • response to estradiol stimulus
  • performs the following molecular functions:
    • growth factor binding
    • growth hormone receptor activity
    • peptide hormone binding
    • protein homodimerization activity
    • protein kinase binding
    • protein phosphatase binding
    • SH2 domain binding
  • is located in the following cellular components:
    • cell surface
    • cytoplasm
    • extracellular space
    • growth hormone receptor complex
    • integral to membrane
    • integral to plasma membrane
    • mitochondrion
    • neuronal cell body
    • nucleus
    • plasma membrane
    • receptor complex

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Summary text based on GO annotations supported by structural data

• Ghr encodes a protein or proteins that contain the following InterPro domains: Fibronectin, type III, Growth hormone-binding protein, Growth hormone/erythropoietin receptor, ligand binding, Immunoglobulin-like fold, Long hematopoietin receptor, single chain, conserved site, indicating that the gene product:
  • performs the following molecular functions:
    • cytokine receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ghr indicates that it:
  • participates in the following biological processes:
    • endocytosis
  • is located in the following cellular components:
    • extracellular region
    • membrane

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References

1. Cerio RJ et al. (2002) Structurally distinct membrane-associated and soluble forms of GH-binding protein in the mouse. J Endocrinol, 172:321-31. (PubMed:11834450)
2. Gonzalez L et al. (1999) Up-regulation of GH-binding protein by mouse GH in transgenic mice overexpressing GH-releasing hormone. J Endocrinol, 163:299-307. (PubMed:10556780)
3. Herington AC et al. (1983) Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf little mouse. Endocrinology, 112:2032-8. (PubMed:6303755)
4. Pantaleon M et al. (1997) Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis? Proc Natl Acad Sci U S A, 94:5125-30. (PubMed:9144201)
5. Schirra HJ et al. (2008) Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study. PLoS ONE, 3:e2764. (PubMed:18648510)
6. Xu BC et al. (1996) Growth hormone promotes the association of transcription factor STAT5 with the growth hormone receptor. J Biol Chem, 271:19768-73. (PubMed:8702683)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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