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Gene Ontology Classifications
growth hormone receptor

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GO curators for mouse genes have assigned the following annotations to the gene product of Ghr. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Cerio RJ et al. (2002) Structurally distinct membrane-associated and soluble forms of GH-binding protein in the mouse. J Endocrinol, 172:321-31. (PubMed:11834450)
  2. Gonzalez L et al. (1999) Up-regulation of GH-binding protein by mouse GH in transgenic mice overexpressing GH-releasing hormone. J Endocrinol, 163:299-307. (PubMed:10556780)
  3. Herington AC et al. (1983) Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf little mouse. Endocrinology, 112:2032-8. (PubMed:6303755)
  4. Pantaleon M et al. (1997) Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis? Proc Natl Acad Sci U S A, 94:5125-30. (PubMed:9144201)
  5. Schirra HJ et al. (2008) Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study. PLoS ONE, 3:e2764. (PubMed:18648510)
  6. Xu BC et al. (1996) Growth hormone promotes the association of transcription factor STAT5 with the growth hormone receptor. J Biol Chem, 271:19768-73. (PubMed:8702683)

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Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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