About   Help   FAQ
Gene Ontology Classifications
glial fibrillary acidic protein

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gfap. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
  1. Eiraku M et al. (2005) DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Nat Neurosci, 8:873-80. (PubMed:15965470)
  2. Fukami S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res, 43:39-56. (PubMed:12074840)
  3. Gimenez Y Ribotta M et al. (2000) Comparative anatomy of the cerebellar cortex in mice lacking vimentin, GFAP, and both vimentin and GFAP. Glia, 31:69-83. (PubMed:10816608)
  4. Gingras H et al. (2005) Biochemical characterization of the mammalian Cux2 protein. Gene, 344:273-85. (PubMed:15656993)
  5. Ha BK et al. (2000) Localization of gp130 in the developing and adult mouse cerebellum. J Chem Neuroanat, 19:129-41. (PubMed:10989258)
  6. Hughes EG et al. (2004) Loss of glial fibrillary acidic protein results in decreased glutamate transport and inhibition of PKA-induced EAAT2 cell surface trafficking. Brain Res Mol Brain Res, 124:114-23. (PubMed:15135219)
  7. Jing R et al. (2007) Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks. J Cell Sci, 120:1267-77. (PubMed:17356066)
  8. Kinoshita A et al. (2000) Differential localization of septins in the mouse brain J Comp Neurol, 428:223-39. (PubMed:11064363)
  9. Kittappa R et al. (2007) The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol, 5:e325. (PubMed:18076286)
  10. Kleene R et al. (2001) The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. J Biol Chem, 276:21656-63. (PubMed:11283023)
  11. Kuramochi Y et al. (2002) Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization. Brain Res Mol Brain Res, 98:81-92. (PubMed:11834298)
  12. McCall MA et al. (1996) Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology. Proc Natl Acad Sci U S A, 93:6361-6. (PubMed:8692820)
  13. Menet V et al. (2001) Inactivation of the glial fibrillary acidic protein gene, but not that of vimentin, improves neuronal survival and neurite growth by modifying adhesion molecule expression. J Neurosci, 21:6147-58. (PubMed:11487638)
  14. Molthagen M et al. (1996) Apoptotic cell death of photoreceptor cells in mice deficient for the adhesion molecule on glia (AMOG, the beta 2- subunit of the Na, K-ATPase). J Neurocytol, 25:243-55. (PubMed:8793730)
  15. Murthy M et al. (2014) Transcription factor Runx1 inhibits proliferation and promotes developmental maturation in a selected population of inner olfactory nerve layer olfactory ensheathing cells. Gene, 540:191-200. (PubMed:24582971)
  16. Ouyang Q et al. (2013) Christianson Syndrome Protein NHE6 Modulates TrkB Endosomal Signaling Required for Neuronal Circuit Development. Neuron, 80:97-112. (PubMed:24035762)
  17. Parenti R et al. (2010) Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity. Glia, 58:1594-609. (PubMed:20578039)
  18. Rao MV et al. (2002) Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density. J Cell Biol, 159:279-90. (PubMed:12403814)
  19. Reuss B et al. (2003) Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants. J Neurosci, 23:6404-12. (PubMed:12878680)
  20. Sakai K et al. (2003) Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries. J Neurosci, 23:550-60. (PubMed:12533615)
  21. Shibata T et al. (1997) Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord. J Neurosci, 17:9212-9. (PubMed:9364068)
  22. Shimozaki K et al. (2013) Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J Neurosci, 33:4066-75. (PubMed:23447615)
  23. Shiwaku H et al. (2010) Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J, 29:2446-60. (PubMed:20531390)
  24. Smorodchenko A et al. (2009) Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development. Biochim Biophys Acta, 1788:2309-19. (PubMed:19646951)
  25. Stegeman S et al. (2013) Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFbeta-mediated axonogenesis. PLoS One, 8:e68287. (PubMed:23861879)
  26. Takemura M et al. (2002) Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice. J Neurosci, 22:6972-9. (PubMed:12177195)
  27. Triolo D et al. (2006) Loss of glial fibrillary acidic protein (GFAP) impairs Schwann cell proliferation and delays nerve regeneration after damage. J Cell Sci, 119:3981-93. (PubMed:16988027)
  28. Werner HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J Neurosci, 27:7717-30. (PubMed:17634366)
  29. Zou J et al. (2011) Whirlin Replacement Restores the Formation of the USH2 Protein Complex in Whirlin Knockout Photoreceptors. Invest Ophthalmol Vis Sci, 52:2343-51. (PubMed:21212183)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.0
The Jackson Laboratory