Automated description from the Alliance of Genome Resources (Release 5.2.0)
Enables identical protein binding activity. Involved in several processes, including SMAD protein signal transduction; fat cell differentiation; and positive regulation of p38MAPK cascade. Acts upstream of or within with a positive effect on cell migration involved in metanephros development. Acts upstream of or within BMP signaling pathway and positive regulation of neuron differentiation. Located in extracellular space. Is expressed in several structures, including central nervous system; craniocervical region bone; ganglia; limb; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including Klippel-Feil syndrome 1; Leber congenital amaurosis 17; cleft lip; isolated microphthalmia 4; and multiple synostoses syndrome. Orthologous to human GDF6 (growth differentiation factor 6).