Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gc. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Gc
  • participates in the following biological processes:
    • vitamin D metabolic process ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gc:
  • performs the following molecular functions:
    • actin binding
    • vitamin D binding
  • is located in the following cellular components:
    • axon
    • cytosol
    • extracellular space
    • perinuclear region of cytoplasm

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Summary text based on GO annotations supported by structural data

• Gc encodes a protein or proteins that contain the following InterPro domains: Serum albumin, Serum albumin, conserved site, Serum albumin, N-terminal, Serum albumin-like, Vitamin D binding protein, domain III, Vitamin D-binding protein, indicating that the gene product:
  • participates in the following biological processes:
    • transport
    • vitamin transport
  • performs the following molecular functions:
    • vitamin transporter activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gc indicates that it:
  • participates in the following biological processes:
    • transport
  • is located in the following cellular components:
    • extracellular region

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References

1. Masuda S et al. (2004) Insights into Vitamin D metabolism using cyp24 over-expression and knockout systems in conjunction with liquid chromatography/mass spectrometry (LC/MS). J Steroid Biochem Mol Biol, 89-90:149-53. (PubMed:15225763)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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