Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including heart development; negative regulation of apoptotic process; and regulation of gene expression. Acts upstream of or within several processes, including embryonic morphogenesis; heart development; and male gonad development. Located in nucleus. Part of chromatin. Is expressed in several structures, including early conceptus; embryo mesenchyme; gut; heart; and reproductive system. Used to study atrial heart septal defect 2 and congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4).