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Gene Ontology Classifications
GATA binding protein 4

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gata4. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Ackerman KG et al. (2007) Gata4 is necessary for normal pulmonary lobar development. Am J Respir Cell Mol Biol, 36:391-7. (PubMed:17142311)
  2. Anttonen M et al. (2003) FOG-2 and GATA-4 Are Coexpressed in the Mouse Ovary and Can Modulate Mullerian-Inhibiting Substance Expression. Biol Reprod, 68:1333-40. (PubMed:12606418)
  3. Arceci RJ et al. (1993) Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol, 13:2235-46. (PubMed:8455608)
  4. Artus J et al. (2011) The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev Biol, 350:393-404. (PubMed:21146513)
  5. Balla A et al. (2003) Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve. Biol Reprod, 69:1281-93. (PubMed:12801993)
  6. Bosse T et al. (2007) Gata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during development. Am J Physiol Gastrointest Liver Physiol, 292:G1302-14. (PubMed:17272516)
  7. Bosse T et al. (2006) Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Mol Cell Biol, 26:9060-70. (PubMed:16940177)
  8. Brewer AC et al. (2005) GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis. Stem Cells Dev, 14:425-39. (PubMed:16137232)
  9. Crawford SE et al. (2002) Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem, 277:3585-92. (PubMed:11724781)
  10. Crispino JD et al. (2001) Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes Dev, 15:839-44. (PubMed:11297508)
  11. Di Lisi R et al. (1998) Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo. J Biol Chem, 273:25371-80. (PubMed:9738004)
  12. Farin HF et al. (2007) Transcriptional Repression by the T-box Proteins Tbx18 and Tbx15 Depends on Groucho Corepressors. J Biol Chem, 282:25748-59. (PubMed:17584735)
  13. Garg V et al. (2003) GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature, 424:443-7. (PubMed:12845333)
  14. Heikinheimo M et al. (1997) Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary. Endocrinology, 138:3505-14. (PubMed:9231805)
  15. Heineke J et al. (2007) Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest, 117:3198-210. (PubMed:17975667)
  16. Ieda M et al. (2010) Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell, 142:375-86. (PubMed:20691899)
  17. Jacobsen CM et al. (2005) GATA-4:FOG interactions regulate gastric epithelial development in the mouse. Dev Dyn, 234:355-62. (PubMed:16127717)
  18. Kim TG et al. (2004) Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. Mol Cell Biol, 24:10151-60. (PubMed:15542826)
  19. Koshiba-Takeuchi K et al. (2006) Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat Genet, 38:175-183. (PubMed:16380715)
  20. Kuo CT et al. (1997) GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev, 11:1048-60. (PubMed:9136932)
  21. Kyronlahti A et al. (2011) GATA4 regulates Sertoli cell function and fertility in adult male mice. Mol Cell Endocrinol, 333:85-95. (PubMed:21172404)
  22. Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell, 2:497-507. (PubMed:18462699)
  23. Lee S et al. (2012) UTX, a Histone H3-Lysine 27 Demethylase, Acts as a Critical Switch to Activate the Cardiac Developmental Program. Dev Cell, 22:25-37. (PubMed:22192413)
  24. Lee Y et al. (1998) The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. Mol Cell Biol, 18:3120-9. (PubMed:9584153)
  25. Lickert H et al. (2004) Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature, 432:107-12. (PubMed:15525990)
  26. Liu Y et al. (2007) Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc Natl Acad Sci U S A, 104:3859-64. (PubMed:17360443)
  27. Lourenco D et al. (2011) Loss-of-function mutation in GATA4 causes anomalies of human testicular development. Proc Natl Acad Sci U S A, 108:1597-602. (PubMed:21220346)
  28. Maitra M et al. (2009) Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol, 326:368-77. (PubMed:19084512)
  29. Makita T et al. (2005) Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol, 280:59-72. (PubMed:15766748)
  30. McGrew MJ et al. (1996) Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus. Mol Cell Biol, 16:4524-34. (PubMed:8754853)
  31. Molkentin JD et al. (1997) Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev, 11:1061-1072. (PubMed:9136933)
  32. Molkentin JD et al. (1994) Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. Mol Cell Biol, 14:4947-57. (PubMed:8007990)
  33. Moskowitz IP et al. (2011) Cardiac-specific transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. Proc Natl Acad Sci U S A, 108:4006-11. (PubMed:21330551)
  34. Murakami A et al. (2004) SOX7 and GATA-4 are competitive activators of Fgf-3 transcription. J Biol Chem, 279:28564-73. (PubMed:15082719)
  35. Niakan KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev, 24:312-26. (PubMed:20123909)
  36. Payer B et al. (2013) Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. Mol Cell, 52:805-18. (PubMed:24268575)
  37. Philips AS et al. (2007) Analysis of the signals and mechanisms mediating nuclear trafficking of GATA-4. Loss of DNA binding is associated with localization in intranuclear speckles. J Biol Chem, 282:24915-27. (PubMed:17548362)
  38. Plageman TF Jr et al. (2004) Differential expression and function of Tbx5 and Tbx20 in cardiac development. J Biol Chem, 279:19026-34. (PubMed:14978031)
  39. Pu WT et al. (2004) GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev Biol, 275:235-44. (PubMed:15464586)
  40. Rajagopal SK et al. (2007) Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol, 43:677-85. (PubMed:17643447)
  41. Rawnsley DR et al. (2013) The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development. J Biol Chem, 288:24429-40. (PubMed:23836893)
  42. Ritz-Laser B et al. (2005) The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression. Mol Endocrinol, 19:759-70. (PubMed:15539431)
  43. Salisch Sv et al. (2011) Gata4 and Sp1 regulate expression of the erythropoietin receptor in cardiomyocytes. J Cell Mol Med, 15:1963-72. (PubMed:21029371)
  44. Schlesinger J et al. (2011) The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs. PLoS Genet, 7:e1001313. (PubMed:21379568)
  45. Sirard C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev, 12:107-19. (PubMed:9420335)
  46. Soudais C et al. (1995) Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development, 121:3877-88. (PubMed:8582296)
  47. Stennard FA et al. (2003) Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev Biol, 262:206-24. (PubMed:14550786)
  48. Su D et al. (2008) Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Exp Hematol, 36:624-41. (PubMed:18439490)
  49. Trivedi CM et al. (2010) Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Dev Cell, 19:450-9. (PubMed:20833366)
  50. van Berlo JH et al. (2010) The transcription factor GATA-6 regulates pathological cardiac hypertrophy. Circ Res, 107:1032-40. (PubMed:20705924)
  51. Watt AJ et al. (2004) GATA4 is essential for formation of the proepicardium and regulates cardiogenesis. Proc Natl Acad Sci U S A, 101:12573-8. (PubMed:15310850)
  52. Xiang F et al. (2006) Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4. Am J Physiol Heart Circ Physiol, 290:H1997-2006. (PubMed:16603706)
  53. Zeisberg EM et al. (2005) Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest, 115:1522-1531. (PubMed:15902305)
  54. Zhao R et al. (2008) Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev Biol, 317:614-9. (PubMed:18400219)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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