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Gene Ontology Classifications
GATA binding protein 3

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gata3. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Amsen D et al. (2007) Direct regulation of gata3 expression determines the T helper differentiation potential of notch. Immunity, 27:89-99. (PubMed:17658279)
  2. Appler JM et al. (2013) Gata3 is a critical regulator of cochlear wiring. J Neurosci, 33:3679-91. (PubMed:23426694)
  3. Bates DL et al. (2008) Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA. J Mol Biol, 381:1292-306. (PubMed:18621058)
  4. Blanchard AD et al. (2000) Identification and characterization of SKAT-2, a novel Th2-specific zinc finger gene. Eur J Immunol, 30:3100-10. (PubMed:11093124)
  5. Boualia SK et al. (2011) Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for pax2 and emx2. PLoS One, 6:e21529. (PubMed:21731775)
  6. Bull RJ et al. (2002) Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene. Toxicol Appl Pharmacol, 182:55-65. (PubMed:12127263)
  7. Chia I et al. (2011) Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice. Development, 138:2089-97. (PubMed:21521737)
  8. Cook KD et al. (2010) TCR-dependent translational control of GATA-3 enhances Th2 differentiation. J Immunol, 185:3209-16. (PubMed:20696860)
  9. Crawford SE et al. (2002) Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem, 277:3585-92. (PubMed:11724781)
  10. Dardalhon V et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol, 9:1347-55. (PubMed:18997793)
  11. Duncan JS et al. (2011) Limited inner ear morphogenesis and neurosensory development are possible in the absence of GATA3. Int J Dev Biol, 55:297-303. (PubMed:21553382)
  12. Fang TC et al. (2007) Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity, 27:100-10. (PubMed:17658278)
  13. Garcia-Frigola C et al. (2003) Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart development. Gene Expr Patterns, 3:777-83. (PubMed:14643687)
  14. George KM et al. (1994) Embryonic expression and cloning of the murine GATA-3 gene. Development, 120:2673-86. (PubMed:7956841)
  15. Grigorieva IV et al. (2010) Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2. J Clin Invest, 120:2144-55. (PubMed:20484821)
  16. Grote D et al. (2008) Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. PLoS Genet, 4:e1000316. (PubMed:19112489)
  17. Grote D et al. (2006) Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development, 133:53-61. (PubMed:16319112)
  18. Guo L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A, 106:13463-8. (PubMed:19666510)
  19. Horiuchi S et al. (2011) Genome-Wide Analysis Reveals Unique Regulation of Transcription of Th2-Specific Genes by GATA3. J Immunol, 186:6378-89. (PubMed:21536806)
  20. Hosoya T et al. (2009) GATA-3 is required for early T lineage progenitor development. J Exp Med, 206:2987-3000. (PubMed:19934022)
  21. Hwang SS et al. (2010) GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2. Immunology, 131:50-8. (PubMed:20636338)
  22. Karamboulas K et al. (2010) Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals. J Cell Sci, 123:2068-76. (PubMed:20501701)
  23. Karis A et al. (2001) Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear J Comp Neurol, 429:615-30. (PubMed:11135239)
  24. Kaufman CK et al. (2003) GATA-3: an unexpected regulator of cell lineage determination in skin. Genes Dev, 17:2108-22. (PubMed:12923059)
  25. Kidder BL et al. (2010) Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res, 20:458-72. (PubMed:20176728)
  26. Kim PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J Immunol, 177:6650-9. (PubMed:17082577)
  27. Ko LJ et al. (1991) Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. Mol Cell Biol, 11:2778-84. (PubMed:2017177)
  28. Lawoko-Kerali G et al. (2004) GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear. Mech Dev, 121:287-99. (PubMed:15003631)
  29. Li Z et al. (2011) ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat Immunol, 12:178-85. (PubMed:21217760)
  30. Lim KC et al. (2000) Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Nat Genet, 25:209-12. (PubMed:10835639)
  31. Ling KW et al. (2007) GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development. Eur J Immunol, 37:1043-52. (PubMed:17357106)
  32. Liu C et al. (2010) Pet-1 is required across different stages of life to regulate serotonergic function. Nat Neurosci, 13:1190-8. (PubMed:20818386)
  33. Ma GT et al. (1997) GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo. Development, 124:907-14. (PubMed:9043071)
  34. Maeda A et al. (2009) Transcription factor GATA-3 is essential for lens development. Dev Dyn, 238:2280-2291. (PubMed:19623612)
  35. Manaia A et al. (2000) Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites. Development, 127:643-53. (PubMed:10631184)
  36. Ng YK et al. (1994) GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene. Development, 120:3257-66. (PubMed:7720565)
  37. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell, 5:420-33. (PubMed:19796622)
  38. Oliver CH et al. (2012) The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev, 26:1086-97. (PubMed:22588720)
  39. Ono Y et al. (1998) TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol, 18:6939-50. (PubMed:9819382)
  40. Pai SY et al. (2003) Critical roles for transcription factor GATA-3 in thymocyte development. Immunity, 19:863-75. (PubMed:14670303)
  41. Pandolfi PP et al. (1995) Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis [see comments] Nat Genet, 11:40-4. (PubMed:7550312)
  42. Pata I et al. (1999) The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4. Development, 126:5523-31. (PubMed:10556076)
  43. Potvin E et al. (2010) Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3. Mol Cell Biol, 30:5348-63. (PubMed:20855530)
  44. Raid R et al. (2009) Lack of Gata3 results in conotruncal heart anomalies in mouse. Mech Dev, 126:80-9. (PubMed:18955134)
  45. Rivolta MN et al. (1998) GATA3 is downregulated during hair cell differentiation in the mouse cochlea. J Neurocytol, 27:637-47. (PubMed:10447238)
  46. Ruest LB et al. (2004) Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity. Development, 131:4413-23. (PubMed:15306564)
  47. Stellato C et al. (2011) Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR. J Immunol, 187:441-9. (PubMed:21613615)
  48. Taghon T et al. (2007) Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3. Nat Immunol, 8:845-855. (PubMed:17603486)
  49. Ting CN et al. (1996) Transcription factor GATA-3 is required for development of the T-cell lineage. Nature, 384:474-8. (PubMed:8945476)
  50. Tsai FY et al. (1998) Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells. Dev Biol, 196:218-27. (PubMed:9576834)
  51. Tsarovina K et al. (2010) The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons. J Neurosci, 30:10833-43. (PubMed:20702712)
  52. Tsarovina K et al. (2004) Essential role of Gata transcription factors in sympathetic neuron development. Development, 131:4775-86. (PubMed:15329349)
  53. van Hamburg JP et al. (2008) Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur J Immunol, 38:2573-86. (PubMed:18792410)
  54. Wang L et al. (2010) The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur J Immunol, 40:2385-90. (PubMed:20706986)
  55. Wang L et al. (2008) Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol, 9:1122-30. (PubMed:18776904)
  56. Wei G et al. (2011) Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity, 35:299-311. (PubMed:21867929)
  57. Yagi R et al. (2010) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity, 32:507-17. (PubMed:20399120)
  58. Zhang DH et al. (1999) Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity, 11:473-82. (PubMed:10549629)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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