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Gene Ontology Classifications
Symbol
Name
ID
Gata2
GATA binding protein 2
MGI:95662

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gata2. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Charles MA et al. (2006) Pituitary-specific gata2 knockout: effects on gonadotrope and thyrotrope function. Mol Endocrinol, 20:1366-77. (PubMed:16543408)
  2. Craven SE et al. (2004) Gata2 specifies serotonergic neurons downstream of sonic hedgehog. Development, 131:1165-73. (PubMed:14973276)
  3. Crawford SE et al. (2002) Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem, 277:3585-92. (PubMed:11724781)
  4. Dasen JS et al. (1999) Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. Cell, 97:587-98. (PubMed:10367888)
  5. de Pooter RF et al. (2006) Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors. J Immunol, 176:5267-75. (PubMed:16621992)
  6. El Wakil A et al. (2006) The GATA2 transcription factor negatively regulates the proliferation of neuronal progenitors. Development, 133:2155-65. (PubMed:16672344)
  7. Gordon DF et al. (1997) Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoter. J Biol Chem, 272:24339-47. (PubMed:9305891)
  8. Haugas M et al. (2010) Gata2 is required for the development of inner ear semicircular ducts and the surrounding perilymphatic space. Dev Dyn, null:null. (PubMed:20652952)
  9. Joshi K et al. (2009) LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. Neuron, 61:839-51. (PubMed:19323994)
  10. Kala K et al. (2009) Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons. Development, 136:253-62. (PubMed:19088086)
  11. Kitajima K et al. (2006) Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2. Blood, 107:1857-63. (PubMed:16254139)
  12. Landry JR et al. (2008) Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver. Blood, 111:3005-14. (PubMed:18184866)
  13. Ma GT et al. (1997) GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo. Development, 124:907-14. (PubMed:9043071)
  14. Nagayama K et al. (2008) Inhibition of GATA2-dependent transactivation of the TSHbeta gene by ligand-bound estrogen receptor alpha. J Endocrinol, 199:113-25. (PubMed:18653622)
  15. Nardelli J et al. (1999) Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Dev Biol, 210:305-21. (PubMed:10357893)
  16. Ng YK et al. (1994) GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene. Development, 120:3257-66. (PubMed:7720565)
  17. Pimanda JE et al. (2007) Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. Proc Natl Acad Sci U S A, 104:17692-7. (PubMed:17962413)
  18. Rodrigues NP et al. (2005) Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood, 106:477-84. (PubMed:15811962)
  19. Tsai FY et al. (1994) An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature, 371:221-6. (PubMed:8078582)
  20. Tsai J et al. (2005) The transcription factor GATA2 regulates differentiation of brown adipocytes. EMBO Rep, 6:879-84. (PubMed:16082385)
  21. Virolainen SM et al. (2012) Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres. Development, 139:3795-805. (PubMed:22991444)
  22. Wozniak RJ et al. (2008) Molecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesis. Mol Cell Biol, 28:6681-94. (PubMed:18779319)
  23. Yu YL et al. (2002) GATA factors are essential for transcription of the survival gene E4bp4 and the viability response of interleukin-3 in Ba/F3 hematopoietic cells. J Biol Chem, 277:27144-53. (PubMed:12023274)
  24. Zhou Y et al. (1998) Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development. EMBO J, 17:6689-700. (PubMed:9822612)
  25. Zhou Y et al. (2000) GATA2 is required for the generation of V2 interneurons. Development, 127:3829-38. (PubMed:10934027)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory