About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Gata1
GATA binding protein 1
MGI:95661

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gata1. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Calligaris R et al. (1995) Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor. Proc Natl Acad Sci U S A, 92:11598-602. (PubMed:8524811)
  2. Crawford SE et al. (2002) Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem, 277:3585-92. (PubMed:11724781)
  3. Crossley M et al. (1994) Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1. J Biol Chem, 269:15440-4. (PubMed:8195185)
  4. Fujiwara Y et al. (1996) Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci U S A, 93:12355-8. (PubMed:8901585)
  5. Gutierrez L et al. (2007) Gata1 regulates dendritic-cell development and survival. Blood, 110:1933-41. (PubMed:17505015)
  6. Holmes M et al. (1999) hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation. J Biol Chem, 274:23491-8. (PubMed:10438528)
  7. Hong W et al. (2002) Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68. Mol Cancer Res, 1:48-55. (PubMed:12496368)
  8. Hughan SC et al. (2005) Selective impairment of platelet activation to collagen in the absence of GATA1. Blood, 105:4369-76. (PubMed:15701726)
  9. Kacena MA et al. (2004) Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2. J Bone Miner Res, 19:652-60. (PubMed:15005853)
  10. Kim CG. (1996) Knock-out effects of transcription factor GATA-1 on early erythropoiesis. Mol Cells, 6:176-182.
  11. Kramer MF et al. (2000) Transcriptional regulation of the murine erythroid-specific 5-aminolevulinate synthase gene. Gene, 247:153-66. (PubMed:10773455)
  12. Liew CK et al. (2005) Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction. Proc Natl Acad Sci U S A, 102:583-8. (PubMed:15644435)
  13. Liu LR et al. (2005) T to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic mice. J Biol Chem, 280:7452-9. (PubMed:15613485)
  14. Nichols KE et al. (2000) Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nat Genet, 24:266-70. (PubMed:10700180)
  15. Osada H et al. (1995) Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. Proc Natl Acad Sci U S A, 92:9585-9. (PubMed:7568177)
  16. Pevny L et al. (1995) Development of hematopoietic cells lacking transcription factor GATA-1. Development, 121:163-72. (PubMed:7867497)
  17. Pevny L et al. (1991) Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature, 349:257-60. (PubMed:1987478)
  18. Philips AS et al. (2007) Analysis of the signals and mechanisms mediating nuclear trafficking of GATA-4. Loss of DNA binding is associated with localization in intranuclear speckles. J Biol Chem, 282:24915-27. (PubMed:17548362)
  19. Potvin E et al. (2010) Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3. Mol Cell Biol, 30:5348-63. (PubMed:20855530)
  20. Qamar I et al. (2009) ARR19 (Androgen Receptor Corepressor of 19 kDa), an Antisteroidogenic Factor, Is Regulated by GATA-1 in Testicular Leydig Cells. J Biol Chem, 284:18021-32. (PubMed:19398553)
  21. Shivdasani RA et al. (1997) A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J, 16:3965-73. (PubMed:9233806)
  22. Simon MC et al. (1992) Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells. Nat Genet, 1:92-8. (PubMed:1302015)
  23. Sugiyama D et al. (2008) Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation. Blood, 111:1924-32. (PubMed:18063754)
  24. Takahashi S et al. (1997) Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene. J Biol Chem, 272:12611-5. (PubMed:9139715)
  25. Takahashi S et al. (1998) Differential regulation of coproporphyrinogen oxidase gene between erythroid and nonerythroid cells. Blood, 92:3436-44. (PubMed:9787185)
  26. Taxman DJ et al. (1995) Erythropoietin-induced transcription at the murine beta maj-globin promoter. A central role for GATA-1. J Biol Chem, 270:6619-27. (PubMed:7896801)
  27. Trainor CD et al. (2009) GATA-1 associates with and inhibits p53. Blood, 114:165-73. (PubMed:19411634)
  28. Tripic T et al. (2009) SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood, 113:2191-201. (PubMed:19011221)
  29. Tsai FY et al. (1998) Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells. Dev Biol, 196:218-27. (PubMed:9576834)
  30. Tsang AP et al. (1997) FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell, 90:109-19. (PubMed:9230307)
  31. Weiss MJ et al. (1995) Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc Natl Acad Sci U S A, 92:9623-7. (PubMed:7568185)
  32. Wu D et al. (2011) Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science, 332:243-7. (PubMed:21436399)
  33. Yamaguchi Y et al. (1998) Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation. Blood, 91:450-7. (PubMed:9427697)
  34. Yomogida K et al. (1994) Developmental stage- and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells. Development, 120:1759-66. (PubMed:7924983)
  35. Yu C et al. (2002) X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. Blood, 100:2040-5. (PubMed:12200364)
  36. Yu YL et al. (2002) GATA factors are essential for transcription of the survival gene E4bp4 and the viability response of interleukin-3 in Ba/F3 hematopoietic cells. J Biol Chem, 277:27144-53. (PubMed:12023274)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/11/2014
MGI 5.20
The Jackson Laboratory