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Gene Ontology Classifications
Symbol
Name
ID
Fshr
follicle stimulating hormone receptor
MGI:95583

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fshr. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 3, 2012. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Abel MH et al. (2008) Spermatogenesis and sertoli cell activity in mice lacking sertoli cell receptors for follicle-stimulating hormone and androgen. Endocrinology, 149:3279-85. (PubMed:18403489)
  2. Abel MH et al. (2000) The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction. Endocrinology, 141:1795-803. (PubMed:10803590)
  3. Balla A et al. (2003) Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve. Biol Reprod, 69:1281-93. (PubMed:12801993)
  4. Belo NO et al. (2008) Impairment of the natriuretic peptide system in follitropin receptor knockout mice and reversal by estradiol: implications for obesity-associated hypertension in menopause. Endocrinology, 149:1399-406. (PubMed:18063689)
  5. Chen X et al. (2006) Aberrant expression of PDGF ligands and receptors in the tumor prone ovary of follitropin receptor knockout (FORKO) mouse. Carcinogenesis, 27:903-15. (PubMed:16344272)
  6. Danilovich N et al. (2001) Ovarian pathology and high incidence of sex cord tumors in follitropin receptor knockout (FORKO) mice. Endocrinology, 142:3673-84. (PubMed:11459817)
  7. Danilovich N et al. (2003) The menopausal mouse: a new neural paradigm of a distressing human condition. Neuroreport, 14:1617-22. (PubMed:14502087)
  8. Danilovich N et al. (2003) Age-related neurodegenerative changes in the central nervous system of estrogen-deficient follitropin receptor knockout mice. Exp Neurol, 183:559-72. (PubMed:14552897)
  9. Danilovich N et al. (2000) Estrogen deficiency, obesity, and skeletal abnormalities in follicle-stimulating hormone receptor knockout (FORKO) female mice Endocrinology, 141:4295-308. (PubMed:11089565)
  10. Danilovich N et al. (2002) Haploinsufficiency of the follicle-stimulating hormone receptor accelerates oocyte loss inducing early reproductive senescence and biological aging in mice. Biol Reprod, 67:361-9. (PubMed:12135868)
  11. Dierich A et al. (1998) Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci U S A, 95:13612-7. (PubMed:9811848)
  12. Ebrahimian T et al. (2008) Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause. Am J Physiol Heart Circ Physiol, 295:H1481-8. (PubMed:18676690)
  13. Gao J et al. (2007) Altered ovarian function affects skeletal homeostasis independent of the action of follicle-stimulating hormone. Endocrinology, 148:2613-21. (PubMed:17332067)
  14. Grover A et al. (2005) Effects of FSH receptor deletion on epididymal tubules and sperm morphology, numbers, and motility. Mol Reprod Dev, 72:135-44. (PubMed:15973687)
  15. Grover A et al. (2004) Structural and functional modifications of sertoli cells in the testis of adult follicle-stimulating hormone receptor knockout mice. Biol Reprod, 71:117-29. (PubMed:14998910)
  16. Krishnamurthy H et al. (2001) Delay in sexual maturity of the follicle-stimulating hormone receptor knockout male mouse. Biol Reprod, 65:522-31. (PubMed:11466221)
  17. Krishnamurthy H et al. (2000) Qualitative and quantitative decline in spermatogenesis of the follicle-stimulating hormone receptor knockout (FORKO) mouse. Biol Reprod, 62:1146-59. (PubMed:10775161)
  18. Sun L et al. (2006) FSH directly regulates bone mass. Cell, 125:247-60. (PubMed:16630814)
  19. Takase M et al. (1997) Inhibitory role of prolactin in the downregulation of testicular follicle-stimulating hormone receptors in mice. J Exp Zool, 278:234-42. (PubMed:9206032)
  20. Tam J et al. (2002) Chronic estrogen deficiency leads to molecular aberrations related to neurodegenerative changes in follitropin receptor knockout female mice. Neuroscience, 114:493-506. (PubMed:12204217)
  21. Tena-Sempere M et al. (1999) Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid: functional expression of alternatively spliced variants and receptor inactivation by a C566T transition in exon 7 of the coding sequence. Biol Reprod, 60:1515-27. (PubMed:10330114)
  22. Veliz LP et al. (2008) Functional role of gap junctions in cytokine-induced leukocyte adhesion to endothelium in vivo. Am J Physiol Heart Circ Physiol, 295:H1056-H1066. (PubMed:18599597)
  23. Xing W et al. (2003) Role of follitropin receptor signaling in nuclear protein transitions and chromatin condensation during spermatogenesis. Biochem Biophys Res Commun, 312:697-701. (PubMed:14680821)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory