Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fkbp4. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Fkbp4
  • participates in the following biological processes:
    • protein complex localization ^[3]
    • steroid hormone receptor complex assembly ^{[1, 3]}
  • performs the following molecular functions:
    • ATP binding ^[1]
    • glucocorticoid receptor binding ^{[1, 5]}
    • GTP binding ^[1]
    • heat shock protein binding ^[1]
    • phosphoprotein binding ^[1]
  • is located in the following cellular components:
    • nucleus ^[1]
• The gene product of Fkbp4 has been shown to bind to the gene products of Nr3c1. ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Fkbp4
  • participates in the following biological processes:
    • androgen receptor signaling pathway ^[6]
    • embryo implantation ^{[4, 6]}
    • male sex differentiation ^[2]
    • prostate gland development ^[6]
    • reproductive structure development ^[6]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fkbp4:
  • participates in the following biological processes:
    • copper ion transport
    • negative regulation of microtubule polymerization
    • peptidyl-proline modification
  • performs the following molecular functions:
    • copper-dependent protein binding
    • FK506 binding
    • heat shock protein binding
    • peptidyl-prolyl cis-trans isomerase activity
    • tau protein binding
  • is located in the following cellular components:
    • axonal growth cone
    • cytoplasm
    • cytosol
    • membrane
    • neuron projection
    • neuronal cell body
    • nucleus
    • perinuclear region of cytoplasm
    • protein complex

---

Summary text based on GO annotations supported by structural data

• Fkbp4 encodes a protein or proteins that contain the following InterPro domains: Elongated TPR repeat-containing domain, Peptidyl-prolyl cis-trans isomerase, FKBP-type, Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain, Tetratricopeptide repeat, Tetratricopeptide repeat-containing domain, Tetratricopeptide TPR-1, Tetratricopeptide-like helical, indicating that the gene product:
  • participates in the following biological processes:
    • protein folding

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fkbp4 indicates that it:
  • participates in the following biological processes:
    • protein folding
  • performs the following molecular functions:
    • isomerase activity
  • is located in the following cellular components:
    • cytoskeleton
    • microtubule

---

References

1. Alnemri ES et al. (1993) Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein. Proc Natl Acad Sci U S A, 90:6839-43. (PubMed:8341706)
2. Cheung-Flynn J et al. (2005) Physiological role for the cochaperone FKBP52 in androgen receptor signaling. Mol Endocrinol, 19:1654-66. (PubMed:15831525)
3. Davies TH et al. (2002) A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. J Biol Chem, 277:4597-600. (PubMed:11751894)
4. Kuhner MK et al. (1989) DNA sequences of mouse H-2 and Qa genes. Immunogenetics, 30:458-64. (PubMed:2592022)
5. Schmitt J et al. (1993) Cloning and expression of a mouse cDNA encoding p59, an immunophilin that associates with the glucocorticoid receptor. Gene, 132:267-71. (PubMed:7693550)
6. Yong W et al. (2007) Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology. J Biol Chem, 282:5026-36. (PubMed:17142810)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---