Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits fibroblast growth factor binding activity. Involved in several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Localizes to excitatory synapse and nucleus. Predicted to colocalize with collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Beare-Stevenson cutis gyrata syndrome; Crouzon syndrome; Pfeiffer syndrome; acrocephalosyndactylia; and intestinal atresia. Human ortholog(s) of this gene implicated in several diseases, including Antley-Bixler syndrome; Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; reproductive organ cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2).