Automated description from the Alliance of Genome Resources
Exhibits SH2 domain binding activity; fibroblast growth factor binding activity; and fibroblast growth factor-activated receptor activity. Involved in several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of animal organ morphogenesis. Localizes to the plasma membrane. Used to study Pfeiffer syndrome and otitis media. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; acrocephalosyndactylia (multiple); cleft lip; hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human FGFR1 (fibroblast growth factor receptor 1).
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