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Gene Ontology Classifications
Fas (TNF receptor superfamily member 6)

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GO curators for mouse genes have assigned the following annotations to the gene product of Fas. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Boldin MP et al. (1995) A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem, 270:7795-8. (PubMed:7536190)
  2. Boone DL et al. (2003) Fas is not essential for lamina propria T lymphocyte homeostasis. Am J Physiol Gastrointest Liver Physiol, 285:G382-8. (PubMed:12702495)
  3. Byth KF et al. (1996) CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J Exp Med, 183:1707-18. (PubMed:8666928)
  4. Camargo FD et al. (2007) YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol, 17:2054-60. (PubMed:17980593)
  5. Chakrabandhu K et al. (2007) Palmitoylation is required for efficient Fas cell death signaling. EMBO J, 26:209-20. (PubMed:17159908)
  6. Chu K et al. (1995) A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc Natl Acad Sci U S A, 92:11894-8. (PubMed:8524870)
  7. Datta SR et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell, 3:631-43. (PubMed:12431371)
  8. Davidson WF et al. (1984) Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice. J Immunol, 133:1048-56. (PubMed:6610701)
  9. Estelles A et al. (1999) The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis. Dev Biol, 216:16-28. (PubMed:10588860)
  10. Gomez-Sintes R et al. (2010) NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. J Clin Invest, 120:2432-45. (PubMed:20530871)
  11. Haraldsson MK et al. (2008) The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. Immunity, 28:40-51. (PubMed:18199416)
  12. Hiatt K et al. (2004) Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am J Pathol, 164:1471-9. (PubMed:15039234)
  13. Hughes DP et al. (1995) A naturally occurring soluble isoform of murine Fas generated by alternative splicing. J Exp Med, 182:1395-401. (PubMed:7595210)
  14. Itoh S et al. (2008) Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells. Genes Cells, 13:355-63. (PubMed:18363966)
  15. Kishimoto H et al. (1999) Several different cell surface molecules control negative selection of medullary thymocytes. J Exp Med, 190:65-73. (PubMed:10429671)
  16. Li S et al. (2002) Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis. J Biol Chem, 277:26912-20. (PubMed:12011074)
  17. Li T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ, 7:107-14. (PubMed:8788039)
  18. Nam YJ et al. (2004) Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Mol Cell, 15:901-12. (PubMed:15383280)
  19. Perlman R et al. (2001) TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Nat Cell Biol, 3:708-14. (PubMed:11483955)
  20. Piazzolla D et al. (2005) Raf-1 sets the threshold of Fas sensitivity by modulating Rok-{alpha} signaling. J Cell Biol, 171:1013-22. (PubMed:16365167)
  21. Rochat-Steiner V et al. (2000) FIST/HIPK3. A Fas/fadd-interacting serine/threonine kinase that induces fadd phosphorylation and inhibits fas-mediated jun nh(2)-terminal kinase activation J Exp Med, 192:1165-74. (PubMed:11034606)
  22. Schenten D et al. (2006) M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. Blood, 107:4849-56. (PubMed:16493007)
  23. Strasser A et al. (1995) Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J, 14:6136-47. (PubMed:8557033)
  24. Sun H et al. (2008) TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell, 133:415-26. (PubMed:18455983)
  25. Suzuki A et al. (1996) Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract. Oncogene, 13:31-7. (PubMed:8700551)
  26. Takahashi T et al. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell, 76:969-76. (PubMed:7511063)
  27. Tamura A et al. (1995) Age-dependent reduction of Bcl-2 expression in peripheral T cells of lpr and gld mutant mice. J Immunol, 155:499-507. (PubMed:7602121)
  28. Tamura A et al. (1996) Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice. Cell Immunol, 168:220-8. (PubMed:8640868)
  29. Tao RH et al. (2011) PMLRARalpha binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo. Blood, 118:3107-18. (PubMed:21803845)
  30. Traver D et al. (1998) Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Immunity, 9:47-57. (PubMed:9697835)
  31. Ugolini G et al. (2003) Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo. J Neurosci, 23:8526-31. (PubMed:13679421)
  32. Vanlangenakker N et al. (2011) cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ, 18:656-65. (PubMed:21052097)
  33. Vogel KU et al. (2013) Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation. Immunity, 38:655-68. (PubMed:23583643)
  34. Wang L et al. (2010) The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat Struct Mol Biol, 17:1324-9. (PubMed:20935634)
  35. Wei MC et al. (2000) tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev, 14:2060-71. (PubMed:10950869)
  36. Yang X et al. (1997) Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell, 89:1067-76. (PubMed:9215629)
  37. Yokota A et al. (2003) Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody. Microbiol Immunol, 47:285-93. (PubMed:12801066)
  38. Zaltsman Y et al. (2010) MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat Cell Biol, 12:553-62. (PubMed:20436477)
  39. Zhang M et al. (2011) Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis. Free Radic Biol Med, 50:1252-62. (PubMed:21382479)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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