Automated description from the Alliance of Genome Resources
Exhibits TFIID-class transcription factor complex binding activity and promoter-specific chromatin binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity and DNA binding activity. Involved in several processes, including DNA metabolic process; gamete generation; and positive regulation of nucleobase-containing compound metabolic process. Predicted to localize to the nucleus. Used to study XFE progeroid syndrome. Human ortholog(s) of this gene implicated in several diseases, including azoospermia; carcinoma (multiple); hematologic cancer (multiple); kidney failure; and transient cerebral ischemia. Is expressed in brain; cerebral cortex; and telencephalon. Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit).