Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Erbb3. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Erbb3
  • is located in the following cellular components:
    • apical plasma membrane ^[1]
    • lateral plasma membrane ^[1]
• The gene product of Erbb3 has been shown to bind to the gene products of Cdk5, Cdk5r1, Erbb2. ^{[3, 5]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Erbb3
  • participates in the following biological processes:
    • cranial nerve development ^[4]
    • endocardial cushion development ^[2]
    • negative regulation of neuron apoptotic process ^[4]
    • peripheral nervous system development ^[2]
    • Schwann cell differentiation ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Erbb3:
  • participates in the following biological processes:
    • negative regulation of cell adhesion
    • negative regulation of secretion
    • negative regulation of signal transduction
    • neuron apoptotic process
    • phosphatidylinositol 3-kinase cascade
    • positive regulation of glucose import
    • positive regulation of protein tyrosine kinase activity
    • regulation of cell proliferation
    • signal transduction
    • transmembrane receptor protein tyrosine kinase signaling pathway
  • performs the following molecular functions:
    • growth factor binding
    • protein heterodimerization activity
    • protein tyrosine kinase activator activity
  • is located in the following cellular components:
    • basolateral plasma membrane
    • extracellular space
    • nucleus
    • postsynaptic membrane

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Summary text based on GO annotations supported by structural data

• Erbb3 encodes a protein or proteins that contain the following InterPro domains: EGF receptor, L domain, Furin-like cysteine-rich domain, Furin-like repeat, Growth factor, receptor, Protein kinase, catalytic domain, Protein kinase-like domain, Serine-threonine/tyrosine-protein kinase catalytic domain, Tyrosine protein kinase, EGF/ERB/XmrK receptor, Tyrosine-protein kinase, active site, Tyrosine-protein kinase, catalytic domain, indicating that the gene product:
  • participates in the following biological processes:
    • protein phosphorylation
    • signal transduction
    • signal transduction by phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • protein kinase activity
    • receptor signaling protein tyrosine kinase activity
    • transferase activity, transferring phosphorus-containing groups
    • transmembrane receptor protein tyrosine kinase activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Erbb3 indicates that it:
  • participates in the following biological processes:
    • phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • nucleotide binding
    • transferase activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
• Erbb3 has been associated with the Enzyme Commission numbers: 2.7.10.1, which implies that the gene product:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • transmembrane receptor protein tyrosine kinase activity

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References

1. Brown N et al. (2004) Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse. Biol Reprod, 71:2003-11. (PubMed:15306553)
2. Erickson SL et al. (1997) ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development, 124:4999-5011. (PubMed:9362461)
3. Fu AK et al. (2001) Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Nat Neurosci, 4:374-81. (PubMed:11276227)
4. Riethmacher D et al. (1997) Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature, 389:725-30. (PubMed:9338783)
5. Sakamoto K et al. (2010) Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer. Oncogene, 29:5359-69. (PubMed:20639901)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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