Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ephx1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ephx1
  • participates in the following biological processes:
    • cellular aromatic compound metabolic process ^[1]
    • response to organic cyclic compound ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ephx1:
  • performs the following molecular functions:
    • enzyme binding
    • epoxide hydrolase activity
  • is located in the following cellular components:
    • intracellular membrane-bounded organelle

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Summary text based on GO annotations supported by structural data

• Ephx1 encodes a protein or proteins that contain the following InterPro domains: Alpha/beta hydrolase fold-1, Epoxide hydrolase, Epoxide hydrolase, N-terminal, Epoxide hydrolase-like, indicating that the gene product:
  • performs the following molecular functions:
    • catalytic activity
    • cis-stilbene-oxide hydrolase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ephx1 indicates that it:
  • participates in the following biological processes:
    • aromatic compound catabolic process
    • response to toxin
  • performs the following molecular functions:
    • hydrolase activity
  • is located in the following cellular components:
    • endoplasmic reticulum
    • integral to membrane
    • membrane
• Ephx1 has been associated with the Enzyme Commission numbers: 3.3.2.9, which implies that the gene product:
  • performs the following molecular functions:
    • cis-stilbene-oxide hydrolase activity

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References

1. Miyata M et al. (1999) Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene. J Biol Chem, 274:23963-8. (PubMed:10446164)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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