Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits protein homodimerization activity and transforming growth factor beta binding activity. Predicted to contribute to BMP binding activity. Involved in several processes, including circulatory system development; positive regulation of vasculature development; and regulation of gene expression. Localizes to endothelial microparticle. Is expressed in several structures, including brain; cardiovascular system; extraembryonic vascular system; and lung. Used to study arteriovenous malformations of the brain and hereditary hemorrhagic telangiectasia. Human ortholog(s) of this gene implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Orthologous to human ENG (endoglin).