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Gene Ontology Classifications
Symbol
Name
ID
Emx2
empty spiracles homeobox 2
MGI:95388

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Emx2. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Bishop KM et al. (2002) Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex. J Neurosci, 22:7627-38. (PubMed:12196586)
  2. Bishop KM et al. (2003) Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding. J Comp Neurol, 457:345-60. (PubMed:12561075)
  3. Boualia SK et al. (2011) Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for pax2 and emx2. PLoS One, 6:e21529. (PubMed:21731775)
  4. Hamasaki T et al. (2004) EMX2 regulates sizes and positioning of the primary sensory and motor areas in neocortex by direct specification of cortical progenitors. Neuron, 43:359-72. (PubMed:15294144)
  5. Kimura J et al. (2005) Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium. J Neurosci, 25:5097-108. (PubMed:15917450)
  6. Li H et al. (2006) Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Mol Cell Neurosci, 33:136-49. (PubMed:16919471)
  7. Lopez-Bendito G et al. (2002) Role of Emx2 in the development of the reciprocal connectivity between cortex and thalamus. J Comp Neurol, 451:153-69. (PubMed:12209834)
  8. Muzio L et al. (2003) Emx1, emx2 and pax6 in specification, regionalization and arealization of the cerebral cortex. Cereb Cortex, 13:641-7. (PubMed:12764040)
  9. Shinozaki K et al. (2004) Emx1 and Emx2 cooperate in initial phase of archipallium development. Mech Dev, 121:475-89. (PubMed:15147765)
  10. Shinozaki K et al. (2002) Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double mutant cerebral cortex. Development, 129:3479-92. (PubMed:12091317)
  11. Tole S et al. (2000) Emx2 is required for growth of the hippocampus but not for hippocampal field specification. J Neurosci, 20:2618-25. (PubMed:10729342)
  12. Wlodarczyk BC et al. (1996) Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology, 54:284-97. (PubMed:9098922)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory