Automated description from the Alliance of Genome Resources
Exhibits several functions, including RNA polymerase II activating transcription factor binding activity; RNA polymerase II distal enhancer sequence-specific DNA binding activity; and SUMO ligase activity. Involved in several processes, including nervous system development; protein sumoylation; and skeletal muscle cell differentiation. Localizes to the cytoplasm and nucleus. Used to study Charcot-Marie-Tooth disease type 4E. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Is expressed in several structures, including genitourinary system; head mesenchyme derived from neural crest; nervous system; neural ectoderm; and vibrissa. Orthologous to human EGR2 (early growth response 2).