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Gene Ontology Classifications
early growth response 2

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Egr2. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Birsoy K et al. (2008) Transcriptional regulation of adipogenesis by KLF4. Cell Metab, 7:339-47. (PubMed:18396140)
  2. Darbas A et al. (2004) Cell autonomy of the mouse claw paw mutation. Dev Biol, 272:470-82. (PubMed:15282162)
  3. Dillon RL et al. (2007) An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer. Mol Cell Biol, 27:8648-57. (PubMed:17938205)
  4. Garcia-Dominguez M et al. (2006) PIASxbeta acts as an activator of Hoxb1 and is antagonized by Krox20 during hindbrain segmentation. EMBO J, 25:2432-42. (PubMed:16675951)
  5. Garcia-Gutierrez P et al. (2011) The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators. EMBO Rep, 12:1018-23. (PubMed:21836637)
  6. Garratt AN et al. (2000) A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool. J Cell Biol, 148:1035-46. (PubMed:10704452)
  7. Gimferrer I et al. (2011) Regulation of GATA-3 Expression during CD4 Lineage Differentiation. J Immunol, 186:3892-8. (PubMed:21357543)
  8. Helmbacher F et al. (1998) Hoxa1 and Krox-20 synergize to control the development of rhombomere 3. Development, 125:4739-48. (PubMed:9806922)
  9. Jacquin TD et al. (1996) Reorganization of pontine rhythmogenic neuronal networks in Krox-20 knockout mice. Neuron, 17:747-58. (PubMed:8893031)
  10. Le N et al. (2005) Nab proteins are essential for peripheral nervous system myelination. Nat Neurosci, 8:932-40. (PubMed:16136673)
  11. Levi G et al. (1996) Defective bone formation in Krox-20 mutant mice. Development, 122:113-20. (PubMed:8565822)
  12. Rajan S et al. (2011) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol Genomics, null:null. (PubMed:22147266)
  13. Schneider-Maunoury S et al. (1993) Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain. Cell, 75:1199-214. (PubMed:7903221)
  14. Sham MH et al. (1993) The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation. Cell, 72:183-96. (PubMed:8093858)
  15. Vesque C et al. (1996) Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site. EMBO J, 15:5383-96. (PubMed:8895582)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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