Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to gamma radiation; circadian temperature homeostasis; and regulation of cellular biosynthetic process. Acts upstream of or within several processes, including BMP signaling pathway; negative regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1).