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Gene Ontology Classifications
Symbol
Name
ID
Egfr
epidermal growth factor receptor
MGI:95294

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Automated description from the Alliance of Genome Resources

Exhibits epidermal growth factor binding activity and epidermal growth factor-activated receptor activity. Predicted to contribute to nitric-oxide synthase regulator activity. Involved in several processes, including animal organ development; positive regulation of cell population proliferation; and protein autophosphorylation. Localizes to several cellular components, including the basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Used to study aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including breast carcinoma; colorectal cancer; lung cancer (multiple); pancreatic cancer; and prostate cancer. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and respiratory system. Orthologous to human EGFR (epidermal growth factor receptor).



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Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement

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Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory