Automated description from the Alliance of Genome Resources
Predicted to have endothelin B receptor binding activity and hormone activity. Involved in several processes, including cellular divalent inorganic cation homeostasis; melanocyte differentiation; and neural crest cell migration. Predicted to localize to the extracellular space. Used to study Hirschsprung's disease and Waardenburg syndrome type 4B. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Waardenburg syndrome type 4B; Waardenburg's syndrome; and congenital central hypoventilation syndrome. Is expressed in several structures, including brain; branchial arch; genitourinary system; gut; and spleen. Orthologous to human EDN3 (endothelin 3).