Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable endothelin B receptor binding activity and hormone activity. Involved in axon extension and axon guidance. Acts upstream of or within several processes, including intracellular monoatomic cation homeostasis; melanocyte differentiation; and neural crest cell migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; branchial arch; genitourinary system; gut; and limb mesenchyme. Used to study Hirschsprung's disease and Waardenburg syndrome type 4B. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Waardenburg syndrome; and Waardenburg syndrome type 4B. Orthologous to human EDN3 (endothelin 3).