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Gene Ontology Classifications
dopamine receptor D5

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Drd5. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 29, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Centonze D et al. (2003) Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons. J Neurosci, 23:6245-54. (PubMed:12867509)
  2. Centonze D et al. (2003) Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity. J Neurosci, 23:8506-12. (PubMed:13679419)
  3. Elliot EE et al. (2003) Locomotor and discriminative-stimulus effects of cocaine in dopamine D5 receptor knockout mice. Psychopharmacology (Berl), 169:161-8. (PubMed:12768268)
  4. Hollon TR et al. (2002) Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive. J Neurosci, 22:10801-10. (PubMed:12486173)
  5. Hunyady B et al. (2001) Susceptibility of dopamine D5 receptor targeted mice to cysteamine. J Physiol Paris, 95:147-51. (PubMed:11595429)
  6. Karper PE et al. (2002) Role of D1-like receptors in amphetamine-induced behavioral sensitization: a study using D1A receptor knockout mice. Psychopharmacology (Berl), 159:407-14. (PubMed:11823893)
  7. Kudwa AE et al. (2005) Dopamine D5 receptor modulates male and female sexual behavior in mice. Psychopharmacology (Berl), 180:206-14. (PubMed:15696326)
  8. Leonard SK et al. (2006) Low affinity binding of the classical D(1) antagonist SCH23390 in rodent brain: Potential interaction with A(2A) and D(2)-like receptors. Brain Res, 1117:25-37. (PubMed:16962565)
  9. Yang Z et al. (2005) D5 dopamine receptor regulation of phospholipase D. Am J Physiol Heart Circ Physiol, 288:H55-61. (PubMed:15598876)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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