Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Drd5. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 29, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Drd5
  • participates in the following biological processes:
    • adenylate cyclase-activating G-protein coupled receptor signaling pathway ^[9]
  • performs the following molecular functions:
    • dopamine neurotransmitter receptor activity, coupled via Gs ^[8]
  • is located in the following cellular components:
    • brush border membrane ^[9]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Drd5
  • participates in the following biological processes:
    • associative learning ^[7]
    • dopamine receptor signaling pathway ^[2]
    • long term synaptic depression ^[2]
    • mating behavior ^[7]
    • negative regulation of blood pressure ^{[4, 9]}
    • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure ^[4]
    • regulation of female receptivity ^[7]
    • response to cocaine ^[3]
    • transmission of nerve impulse ^[1]
    • wound healing ^[5]
  • performs the following molecular functions:
    • dopamine neurotransmitter receptor activity, coupled via Gs ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Drd5
  • participates in the following biological processes:
    • negative regulation of blood pressure based on interactions with Oxtr ^[4]
    • regulation of systemic arterial blood pressure by vasopressin based on interactions with Avpr1a, Avpr1b ^[4]
    • response to amphetamine based on interactions with Drd1a ^[6]
    • sensitization based on interactions with Drd1a ^[6]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Drd5:
  • participates in the following biological processes:
    • adenylate cyclase-activating dopamine receptor signaling pathway
    • adenylate cyclase-activating G-protein coupled receptor signaling pathway
    • cellular response to catecholamine stimulus
    • dopamine receptor signaling pathway
    • negative regulation of cell migration
    • negative regulation of NAD(P)H oxidase activity
    • negative regulation of protein kinase activity
    • positive regulation of adenylate cyclase activity
    • positive regulation of cAMP biosynthetic process
    • reactive oxygen species metabolic process
    • regulation of long-term neuronal synaptic plasticity
    • synaptic transmission, dopaminergic
    • visual learning
  • performs the following molecular functions:
    • dopamine binding
    • dopamine neurotransmitter receptor activity
    • dopamine neurotransmitter receptor activity, coupled via Gs
    • drug binding
    • G-protein alpha-subunit binding
  • is located in the following cellular components:
    • axon
    • brush border membrane
    • dendrite
    • dendritic spine
    • neuronal cell body
    • plasma membrane

---

Summary text based on GO annotations supported by structural data

• Drd5 encodes a protein or proteins that contain the following InterPro domains: Dopamine 1B receptor, Dopamine receptor, GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, indicating that the gene product:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
  • is located in the following cellular components:
    • integral to membrane

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Drd5 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

---

References

1. Centonze D et al. (2003) Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons. J Neurosci, 23:6245-54. (PubMed:12867509)
2. Centonze D et al. (2003) Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity. J Neurosci, 23:8506-12. (PubMed:13679419)
3. Elliot EE et al. (2003) Locomotor and discriminative-stimulus effects of cocaine in dopamine D5 receptor knockout mice. Psychopharmacology (Berl), 169:161-8. (PubMed:12768268)
4. Hollon TR et al. (2002) Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive. J Neurosci, 22:10801-10. (PubMed:12486173)
5. Hunyady B et al. (2001) Susceptibility of dopamine D5 receptor targeted mice to cysteamine. J Physiol Paris, 95:147-51. (PubMed:11595429)
6. Karper PE et al. (2002) Role of D1-like receptors in amphetamine-induced behavioral sensitization: a study using D1A receptor knockout mice. Psychopharmacology (Berl), 159:407-14. (PubMed:11823893)
7. Kudwa AE et al. (2005) Dopamine D5 receptor modulates male and female sexual behavior in mice. Psychopharmacology (Berl), 180:206-14. (PubMed:15696326)
8. Leonard SK et al. (2006) Low affinity binding of the classical D(1) antagonist SCH23390 in rodent brain: Potential interaction with A(2A) and D(2)-like receptors. Brain Res, 1117:25-37. (PubMed:16962565)
9. Yang Z et al. (2005) D5 dopamine receptor regulation of phospholipase D. Am J Physiol Heart Circ Physiol, 288:H55-61. (PubMed:15598876)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---