Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Drd4. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of May 22, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Drd4
  • participates in the following biological processes:
    • adenylate cyclase-inhibiting dopamine receptor signaling pathway ^[5]
    • adult locomotory behavior ^[3]
    • behavioral response to cocaine ^{[2, 3]}
    • fear response ^[1]
    • regulation of dopamine metabolic process ^[3]
    • regulation of inhibitory postsynaptic membrane potential ^{[4, 5]}
    • response to amphetamine ^[3]
  • performs the following molecular functions:
    • dopamine neurotransmitter receptor activity, coupled via Gi/Go ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Drd4:
  • participates in the following biological processes:
    • activation of MAPK activity
    • adenylate cyclase-inhibiting dopamine receptor signaling pathway
    • arachidonic acid secretion
    • associative learning
    • behavioral fear response
    • dopamine receptor signaling pathway
    • negative regulation of adenylate cyclase activity
    • negative regulation of cAMP biosynthetic process
    • negative regulation of protein secretion
    • negative regulation of voltage-gated calcium channel activity
    • olfactory learning
    • positive regulation of kinase activity
    • positive regulation of penile erection
    • positive regulation of sodium:hydrogen antiporter activity
    • regulation of calcium-mediated signaling
    • regulation of neurotransmitter secretion
    • regulation of synaptic transmission
    • response to histamine
    • short-term memory
    • synaptic transmission, dopaminergic
  • performs the following molecular functions:
    • dopamine binding
    • dopamine neurotransmitter receptor activity
    • dopamine neurotransmitter receptor activity, coupled via Gi/Go
    • drug binding
    • SH3 domain binding
  • is located in the following cellular components:
    • axon
    • cell cortex
    • cytoplasm
    • dendrite
    • dendritic spine
    • integral to plasma membrane
    • membrane
    • neuronal cell body
    • plasma membrane
    • terminal button
    • vesicle membrane

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Summary text based on GO annotations supported by structural data

• Drd4 encodes a protein or proteins that contain the following InterPro domains: Dopamine D4 receptor, Dopamine receptor, GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, indicating that the gene product:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Drd4 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane

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References

1. Falzone TL et al. (2002) Absence of dopamine D4 receptors results in enhanced reactivity to unconditioned, but not conditioned, fear. Eur J Neurosci, 15:158-64. (PubMed:11860516)
2. Katz JL et al. (2003) Cocaine-induced locomotor activity and cocaine discrimination in dopamine D4 receptor mutant mice. Psychopharmacology (Berl), 170:108-14. (PubMed:12783155)
3. Rubinstein M et al. (1997) Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell, 90:991-1001. (PubMed:9323127)
4. Rubinstein M et al. (2001) Dopamine D4 receptor-deficient mice display cortical hyperexcitability. J Neurosci, 21:3756-63. (PubMed:11356863)
5. Shin RM et al. (2003) Dopamine D4 receptor-induced postsynaptic inhibition of GABAergic currents in mouse globus pallidus neurons. J Neurosci, 23:11662-72. (PubMed:14684868)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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