Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables G protein-coupled receptor activity; dopamine binding activity; and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including hyaloid vascular plexus regression; negative regulation of innate immune response; and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including dopamine receptor signaling pathway; modulation of chemical synaptic transmission; and nervous system development. Located in axon; dendrite; and presynapse. Is active in several cellular components, including GABA-ergic synapse; dopaminergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Parkinson's disease and primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including drug dependence (multiple); end stage renal disease; nicotine dependence; obesity; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2).
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