Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables selenium binding activity and thyroxine 5'-deiodinase activity. Predicted to be involved in amino acid metabolic process and thyroid hormone metabolic process. Predicted to act upstream of or within hormone biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Is expressed in foregut; intestine; liver and biliary system; and metanephros. Human ortholog(s) of this gene implicated in thyroid gland disease. Orthologous to human DIO1 (iodothyronine deiodinase 1).