Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ddc. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ddc
  • participates in the following biological processes:
    • response to toxic substance ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ddc:
  • participates in the following biological processes:
    • dopamine biosynthetic process
    • serotonin biosynthetic process
    • synaptic vesicle amine transport
  • performs the following molecular functions:
    • amino acid binding
    • aromatic-L-amino-acid decarboxylase activity
    • protein domain specific binding
    • pyridoxal phosphate binding
  • is located in the following cellular components:
    • axon
    • cytoplasm
    • neuronal cell body
    • synaptic vesicle

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Summary text based on GO annotations supported by structural data

• Ddc encodes a protein or proteins that contain the following InterPro domains: Aromatic-L-amino-acid decarboxylase, Pyridoxal phosphate-dependent decarboxylase, Pyridoxal phosphate-dependent transferase, Pyridoxal phosphate-dependent transferase, major region, subdomain 1, Pyridoxal phosphate-dependent transferase, major region, subdomain 2, Pyridoxal-phosphate binding site, indicating that the gene product:
  • participates in the following biological processes:
    • carboxylic acid metabolic process
    • cellular amino acid metabolic process
  • performs the following molecular functions:
    • carboxy-lyase activity
    • catalytic activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ddc indicates that it:
  • participates in the following biological processes:
    • catecholamine biosynthetic process
  • performs the following molecular functions:
    • carboxy-lyase activity
    • lyase activity

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References

1. Eaton MJ et al. (1993) Distribution of aromatic L-amino acid decarboxylase mRNA in mouse brain by in situ hybridization histology. J Comp Neurol, 337:640-54. (PubMed:7904615)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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