Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Acadvl. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

This gene encodes a homodimeric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C16- and C20-acylCoA and localizes to the inner mitochondrial membrane (unlike related acyl-CoA dehydrogenases). In mice, deficiency of this gene can cause ventricular arrhythmias as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Acadvl
  • is located in the following cellular components:
    • mitochondrion ^{[2, 3]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Acadvl
  • participates in the following biological processes:
    • fatty acid beta-oxidation using acyl-CoA dehydrogenase ^[1]
    • negative regulation of fatty acid biosynthetic process ^[1]
    • negative regulation of fatty acid oxidation ^[1]
    • regulation of cholesterol metabolic process ^[1]
    • temperature homeostasis ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Acadvl:
  • participates in the following biological processes:
    • fatty acid beta-oxidation
    • fatty acid beta-oxidation using acyl-CoA dehydrogenase
    • very long-chain fatty acid catabolic process
  • performs the following molecular functions:
    • acyl-CoA dehydrogenase activity
    • fatty-acyl-CoA binding
    • flavin adenine dinucleotide binding
    • long-chain-acyl-CoA dehydrogenase activity
    • very-long-chain-acyl-CoA dehydrogenase activity
  • is located in the following cellular components:
    • mitochondrial inner membrane
    • mitochondrial nucleoid
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Acadvl encodes a protein or proteins that contain the following InterPro domains: Acyl-CoA dehydrogenase, conserved site, Acyl-CoA dehydrogenase, N-terminal, Acyl-CoA dehydrogenase/oxidase, Acyl-CoA dehydrogenase/oxidase C-terminal, Acyl-CoA dehydrogenase/oxidase, N-terminal, Acyl-CoA oxidase/dehydrogenase, central domain, Acyl-CoA oxidase/dehydrogenase, type 1, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • oxidoreductase activity, acting on the CH-CH group of donors

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Acadvl indicates that it:
  • participates in the following biological processes:
    • fatty acid metabolic process
    • lipid metabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • oxidoreductase activity
  • is located in the following cellular components:
    • membrane

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References

1. Goetzman ES et al. (2005) Differential induction of genes in liver and brown adipose tissue regulated by peroxisome proliferator-activated receptor-alpha during fasting and cold exposure in acyl-CoA dehydrogenase-deficient mice. Mol Genet Metab, 84:39-47. (PubMed:15639194)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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