Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ldb2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of January 17, 2011. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins (summarized by Semina et al., 1998 [PubMed 9799849]). These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes (Jurata and Gill, 1997 [PubMed 9315627]). The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 (Bach et al., 1997 [PubMed 9192866]) and Clim2/Lbd1/Nli (Agulnick et al., 1996 [PubMed 8918878]; Jurata et al., 1996 [PubMed 8876198]; Bach et al., 1997 [PubMed 9192866]) and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.[supplied by OMIM, Jul 2010]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ldb2
  • is located in the following cellular components:
    • transcription factor complex ^[2]
• The gene product of Ldb2 has been shown to bind to the gene products of Rlim. ^[1] Researchers have inferred, based on physical interactions, that the gene product of Ldb2
  • performs the following molecular functions:
    • enzyme binding ^[3]
    • transcription factor binding transcription factor activity ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Ldb2
  • participates in the following biological processes:
    • epithelial structure maintenance based on interactions with Ldb1 ^[4]
    • hair follicle development based on interactions with Ldb1 ^[4]
    • positive regulation of cellular component biogenesis based on interactions with Ldb1 ^[4]
    • positive regulation of transcription from RNA polymerase II promoter based on interactions with Lhx3, Pitx1, Rlim ^{[1, 2]}
    • somatic stem cell maintenance based on interactions with Ldb1 ^[4]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ldb2:
  • is located in the following cellular components:
    • nucleus

---

Summary text based on GO annotations supported by structural data

• Ldb2 encodes a protein or proteins that contain the following InterPro domains: LIM-domain binding protein, indicating that the gene product:
  • performs the following molecular functions:
    • LIM domain binding
    • transcription cofactor activity

---

References

1. Bach I et al. (1999) RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat Genet, 22:394-9. (PubMed:10431247)
2. Bach I et al. (1997) A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes Dev, 11:1370-80. (PubMed:9192866)
3. Ostendorff HP et al. (2002) Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature, 416:99-103. (PubMed:11882901)
4. Xu X et al. (2007) Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells. Dev Biol, 312:484-500. (PubMed:17991461)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---