Automated description from the Alliance of Genome Resources
Exhibits N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Involved in several processes, including embryonic skeletal joint development; heparan sulfate proteoglycan biosynthetic process; and nervous system development. Localizes to the integral component of endoplasmic reticulum membrane. Used to study autism spectrum disorder and hereditary multiple exostoses. Human ortholog(s) of this gene implicated in chondrosarcoma; hereditary multiple exostoses; and trichorhinophalangeal syndrome type II. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and limb. Orthologous to human EXT1 (exostosin glycosyltransferase 1).