Automated description from the Alliance of Genome Resources
Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription factor binding activity; and protein dimerization activity. Predicted to contribute to sequence-specific DNA binding activity. Involved in several processes, including animal organ development; positive regulation of cell communication; and regulation of transcription by RNA polymerase II. Localizes to the RNA polymerase II transcription factor complex and cytoplasm. Used to study juvenile polyposis syndrome and osteogenesis imperfecta. Human ortholog(s) of this gene implicated in several diseases, including aortic disease; female reproductive organ cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; and seminoma. Orthologous to human SMAD4 (SMAD family member 4).