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Gene Ontology Classifications
Symbol
Name
ID
Sfrp1
secreted frizzled-related protein 1
MGI:892014

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sfrp1. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of August 18, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
References
  1. . () , :. (PubMed:)
  2. Bodine PV et al. (2005) The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis. J Cell Biochem, 96:1212-30. (PubMed:16149051)
  3. Bodine PV et al. (2009) A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone, 44:1063-8. (PubMed:19254787)
  4. Bodine PV et al. (2004) The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol Endocrinol, 18:1222-37. (PubMed:14976225)
  5. Joesting MS et al. (2008) Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate. Dev Biol, 317:161-73. (PubMed:18371946)
  6. Kwon HS et al. (2009) Myocilin is a modulator of Wnt signaling. Mol Cell Biol, 29:2139-54. (PubMed:19188438)
  7. Li X et al. (2010) Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. J Neurosci, 30:1788-97. (PubMed:20130188)
  8. Matsuyama M et al. (2009) Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet, 5:e1000427. (PubMed:19300477)
  9. Misra K et al. (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev Biol, 337:74-83. (PubMed:19850029)
  10. Nakajima H et al. (2009) Wnt modulators, SFRP-1, and SFRP-2 are expressed in osteoblasts and differentially regulate hematopoietic stem cells. Biochem Biophys Res Commun, 390:65-70. (PubMed:19778523)
  11. Renstrom J et al. (2009) Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells. Cell Stem Cell, 5:157-67. (PubMed:19664990)
  12. Satoh W et al. (2006) Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development, 133:989-99. (PubMed:16467359)
  13. Satoh W et al. (2008) Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse. Genesis, 46:92-103. (PubMed:18257070)
  14. Warr N et al. (2009) Sfrp1 and Sfrp2 are required for normal male sexual development in mice. Dev Biol, 326:273-84. (PubMed:19100252)
  15. Wawrzak D et al. (2007) Wnt3a binds to several sFRPs in the nanomolar range. Biochem Biophys Res Commun, 357:1119-23. (PubMed:17462603)
  16. Yokota T et al. (2008) Soluble Frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis. J Immunol, 181:6061-72. (PubMed:18941195)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory