Automated description from the Alliance of Genome Resources
Predicted to have RNA polymerase I core binding activity; protein heterodimerization activity; and scaffold protein binding activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Predicted to localize to the cytosol; fibrillar center; and nucleoplasm. Used to study Treacher Collins syndrome. Human ortholog(s) of this gene implicated in Treacher Collins syndrome. Is expressed in several structures, including Meckel's cartilage; genitourinary system; liver; musculoskeletal system; and spleen. Orthologous to human TCOF1 (treacle ribosome biogenesis factor 1).