Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables peptidase activity. Acts upstream of or within brain renin-angiotensin system and zymogen activation. Located in extracellular space. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to several human genes including KLK1 (kallikrein 1).