Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Serpina1a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Serpina1a
  • participates in the following biological processes:
    • protein N-linked glycosylation ^[1]
    • response to cytokine stimulus ^[2]
    • response to peptide hormone stimulus ^[2]
  • is located in the following cellular components:
    • extracellular region ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Serpina1a:
  • participates in the following biological processes:
    • negative regulation of endopeptidase activity
    • regulation of proteolysis
    • response to chromate
    • response to lead ion
    • response to methanol
  • performs the following molecular functions:
    • endopeptidase inhibitor activity
    • protease binding
    • serine-type endopeptidase inhibitor activity
  • is located in the following cellular components:
    • extracellular space

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Serpina1a indicates that it:
  • participates in the following biological processes:
    • acute-phase response
    • negative regulation of peptidase activity
  • performs the following molecular functions:
    • peptidase inhibitor activity

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References

1. Barbour KW et al. (2002) Functional Diversification During Evolution of the Murine alpha(1)-Proteinase Inhibitor Family: Role of the Hypervariable Reactive Center Loop. Mol Biol Evol, 19:718-27. (PubMed:11961105)
2. Winkler IG et al. (2005) Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. J Exp Med, 201:1077-88. (PubMed:15795238)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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