Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including in utero embryonic development; protein N-linked glycosylation; and response to peptide hormone. Located in extracellular region. Is expressed in gut; liver lobe; nucleus pulposus; and renal calyx. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; artery disease (multiple); chronic obstructive pulmonary disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human SERPINA1 (serpin family A member 1).