Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cyp17a1. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cyp17a1
  • participates in the following biological processes:
    • glucocorticoid biosynthetic process ^[3]
    • oxidation-reduction process ^[3]
  • performs the following molecular functions:
    • steroid 17-alpha-monooxygenase activity ^[3]
  • is located in the following cellular components:
    • axon ^[2]
    • mitochondrion ^[4]
    • neuronal cell body ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cyp17a1
  • participates in the following biological processes:
    • oxidation-reduction process ^[1]
  • performs the following molecular functions:
    • steroid 17-alpha-monooxygenase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cyp17a1:
  • participates in the following biological processes:
    • hormone biosynthetic process
    • oxidation-reduction process
    • positive regulation of steroid hormone biosynthetic process
    • progesterone metabolic process
    • steroid biosynthetic process
    • steroid metabolic process
  • performs the following molecular functions:
    • heme binding
    • steroid 17-alpha-monooxygenase activity
  • is located in the following cellular components:
    • cell projection
    • endoplasmic reticulum
    • intracellular membrane-bounded organelle
    • neuronal cell body

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Summary text based on GO annotations supported by structural data

• Cyp17a1 encodes a protein or proteins that contain the following InterPro domains: Cytochrome P450, Cytochrome P450, conserved site, Cytochrome P450, E-class, group I, indicating that the gene product:
  • performs the following molecular functions:
    • electron carrier activity
    • iron ion binding
    • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cyp17a1 indicates that it:
  • performs the following molecular functions:
    • lyase activity
    • metal ion binding
    • monooxygenase activity
    • oxidoreductase activity
  • is located in the following cellular components:
    • membrane
• Cyp17a1 has been associated with the Enzyme Commission numbers: 1.14.99.9, 4.1.2.30, which implies that the gene product:
  • performs the following molecular functions:
    • 17-alpha-hydroxyprogesterone aldolase activity

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References

1. Bair SR et al. (2004) Deletion of the mouse P450c17 gene causes early embryonic lethality. Mol Cell Biol, 24:5383-90. (PubMed:15169901)
2. Compagnone NA et al. (1995) Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system. Endocrinology, 136:5212-23. (PubMed:7588260)
3. Keeney DS et al. (1995) Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo. Endocrinology, 136:4872-9. (PubMed:7588219)
4. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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