Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cyp11a1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 29, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cyp11a1
  • participates in the following biological processes:
    • C21-steroid hormone biosynthetic process ^[3]
    • oxidation-reduction process ^[3]
  • performs the following molecular functions:
    • cholesterol monooxygenase (side-chain-cleaving) activity ^[3]
  • is located in the following cellular components:
    • mitochondrion ^{[1, 2, 4]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cyp11a1:
  • participates in the following biological processes:
    • C21-steroid hormone biosynthetic process
    • cholesterol metabolic process
    • mating behavior
    • oxidation-reduction process
    • response to hydrogen peroxide
    • steroid biosynthetic process
  • performs the following molecular functions:
    • cholesterol binding
    • cholesterol monooxygenase (side-chain-cleaving) activity
  • is located in the following cellular components:
    • mitochondrial crista
    • mitochondrial inner membrane
    • mitochondrion
    • perikaryon

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Summary text based on GO annotations supported by structural data

• Cyp11a1 encodes a protein or proteins that contain the following InterPro domains: Cytochrome P450, Cytochrome P450, conserved site, Cytochrome P450, E-class, group I, indicating that the gene product:
  • performs the following molecular functions:
    • electron carrier activity
    • heme binding
    • iron ion binding
    • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cyp11a1 indicates that it:
  • participates in the following biological processes:
    • lipid metabolic process
    • steroid metabolic process
  • performs the following molecular functions:
    • metal ion binding
    • monooxygenase activity
    • oxidoreductase activity
  • is located in the following cellular components:
    • membrane

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References

1. Mellon SH et al. (1993) Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain. Brain Res, 629:283-92. (PubMed:8111631)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. O'Shaughnessy PJ et al. (1994) Development of cytochrome P-450 side chain cleavage mRNA levels in neonatal ovaries of normal and hypogonadal (hpg) mice. Mol Cell Endocrinol, 104:133-8. (PubMed:7527351)
4. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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