Automated description from the Alliance of Genome Resources (Release 5.2.0)
Enables cysteine-type peptidase activity and endopeptidase activity. Involved in proteolysis involved in cellular protein catabolic process; thyroid hormone generation; and viral entry into host cell. Acts upstream of or within decidualization. Located in external side of plasma membrane; extracellular space; and lysosome. Is expressed in several structures, including extraembryonic component; eye; genitourinary system; limb interdigital region; and optic nerve. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B).