Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables corticotrophin-releasing factor receptor activity. Involved in several processes, including cellular response to corticotropin-releasing hormone stimulus; corticotropin secretion; and regulation of corticosterone secretion. Acts upstream of or within behavioral response to ethanol; exploration behavior; and general adaptation syndrome, behavioral process. Predicted to be located in several cellular components, including multivesicular body; neuronal cell body; and trans-Golgi network. Predicted to be active in neuron projection and plasma membrane. Is expressed in several structures, including Leydig cell; brain; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and obesity. Orthologous to several human genes including CRHR1 (corticotropin releasing hormone receptor 1).