Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cp. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

The protein encoded by this gene is a copper-containing glycoprotein found soluble in the serum and GPI-anchored in other tissues. It oxidizes Fe(II) to Fe(III) and is proposed to play an important role in iron homeostasis. In humans mutations of this gene cause aceruloplasminemia, which is characterized by retinal degeneration, diabetes, anemia and neurological symptoms. In mouse deficiency of this gene in combination with a deficiency of its homolog hephaestin causes retinal degeneration and serves as a pathophysiological model for aceruloplasminemia and age-related macular degeneration. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cp
  • participates in the following biological processes:
    • oxidation-reduction process ^[2]
  • performs the following molecular functions:
    • copper ion binding ^{[1, 2]}
    • ferroxidase activity ^[2]
  • is located in the following cellular components:
    • extracellular space ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cp:
  • participates in the following biological processes:
    • response to copper ion
  • performs the following molecular functions:
    • chaperone binding
    • copper ion binding
  • is located in the following cellular components:
    • anchored component of plasma membrane
    • blood microparticle
    • extracellular space
    • extracellular vesicular exosome
    • lysosomal membrane

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Summary text based on GO annotations supported by structural data

• Cp encodes a protein or proteins that contain the following InterPro domains: Ceruloplasmin, Cupredoxin, Multicopper oxidase, copper-binding site, Multicopper oxidase, type 1, Multicopper oxidase, type 2, Multicopper oxidase, type 3, indicating that the gene product:
  • participates in the following biological processes:
    • cellular iron ion homeostasis
    • copper ion transport
  • performs the following molecular functions:
    • oxidoreductase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cp indicates that it:
  • participates in the following biological processes:
    • copper ion transport
    • ion transport
    • transport
  • performs the following molecular functions:
    • metal ion binding
    • oxidoreductase activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Barnes N et al. (2005) The copper-transporting ATPases, menkes and wilson disease proteins, have distinct roles in adult and developing cerebellum. J Biol Chem, 280:9640-5. (PubMed:15634671)
2. Huster D et al. (2006) Consequences of copper accumulation in the livers of the Atp7b-/- (Wilson disease gene) knockout mice. Am J Pathol, 168:423-34. (PubMed:16436657)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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